Copyrighted by the Institute of Enzymology! -----RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME--------MFREDEGYIK---------EEERPLPENEFQR---------------------QVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFR-------DENEDMH---GGGVTFHTYSNSTIGYQQSTSFTDP-FFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADER--DSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY----------------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFK-YRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTFGTTAD------------LEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYYSHTQARSKMPKKRRGVLSLDQVIYFAEI -----RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI--------NKFREDEGFIK---------EEERPLPDNEKQR---------------------KVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGT----------------KIEEDEVPDITDP-FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFI-TLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSEN--SFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEM-------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTFGTTAD------------------------LEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMMPKKRRGVLSLDQVIYFAEI -----RVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAME--------KFRE---------------DEGFLREEERPLPR---------------RDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDP--------FFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY----------------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDL---LLTTFG------TTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYYSHTQARSKMPKKRRGVLSLDQVIYFAEI -----RVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAME--------KFRE---------------DEGFLREEERPLPR---------------RDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDP--------FFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY----------------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDL---LLTTFG------TTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYYSHTQARSKMPKKRRGVLSLDQVIYFAEI -----RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME--------KFREDEGFIK---------EEERPLPEKEYQR---------------------QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDF------TGTIHRIDNTTVIY-TSNIFTDP--------FFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEA--ESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY----------------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDL---LLTTFG--------TTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYYSHTQARSKMPKKRRGVLSLDQVIYFAEI -----RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME--------KFREDEGFIK---------EEERPLPEKEYQR---------------------QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDF------TGTVHRIDNTTVIYNS-NIFTDP--------FFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEA--ESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY----------------------------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTG-KLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDL---LLTTFG--------TTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYYSHTQARSKMPKKRRGVLSLDQVIYFAEI ------IVLNVSGTRFQTWQDTLERYPDTLLGSSERDFF-YHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRE--------------NAERLQDDADT-------DNTGESALPTMTA-RQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVA--------------------------FFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLA----------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHP-GLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLT-TFGTTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSSLDQVIYFAEI ------IVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFF-FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERL-----MD---DNESENNQESM------------PSLSFRQTM----WRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVA--------------------------FFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLA----------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYT-QHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTF-GTTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSSLDQVIYFAEI ------IVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFF-FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCC---YEEYKDRKRENA--ERLMDDNDSE--NNQESM------------PSLSFRQTM----WRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVA--------------------------FFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLA----------- MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELQYWGLDANEVEPCCWMTYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLSTWQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVSEIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNIWFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTF-GTTADLEFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFASLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIGSVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSSLDQVIYFAEI MESEYRVILNVGGIRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFF DRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELQYWGLDANEVEPCCWM TYTQHRDTQEVLATLDKLDIDIDEERLNNEEEIYRRFGWEDDYHNDSLST WQKLKPKIWRLFDEPYSSQGAKVVAVISVFFLIAAILVFCLKTHPGLRVS EIYPMQTNQTFRQSRSNGVTFKYRTESIGVDKTNSKPHPGFLVVETICNI WFTIEITIRFISCPNKIKYFQTPVNVIDLVATITFYVDLLLTTFGTTADL EFFSIIRIMRLFKLTQHSSGLKILMHTFRASAKELMLLVFFLVLGIVVFA SLVYYAERIEVNPDNQFQSIPLGLWWAIVTMTTIGYGDMTPHTYLGRIIG SVCALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSLDQVIY FAEI