<?xml version="1.0"?>
<CCTOPItem id="P25178" transmembrane="yes" evidence="3D">
	<Copyright>Copyrighted by the Institute of Enzymology!</Copyright>
	<Name>Lipoprotein signal peptidase {ECO:0000255|HAMAP-Rule:MF_00161}</Name>
	<CrossRef>
		<UniProt id="LSPA_HELPY">
			<AC>P25178</AC>
		</UniProt>
		<PDBTM id="5dir">
			<Chain id="A"/>
		</PDBTM>
		<TOPDB id="AP04547">
			<Alignment>
				<CrossRefSeq>---------LPWLWITVLVFVLDQVSKAFFQAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVSASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFRSKKS-------</CrossRefSeq>
				<OrigSeq>MLKTTKKSLLVFMGVFFLIFGVDQAIK---YAILEGFRYESLMIDI---VLVFNKGVAFSLLSFLEGGLKYL----QILLILGLFIFLMRQRELFKNHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYG--FDFAIFNFADVMIDVGVGVLLLKQFFFKQKKQNKIKA</OrigSeq>
			</Alignment>
		</TOPDB>
	</CrossRef>
	<Sequence length="157" checkSum="67b2b94c5c9801844edb16ffec543373">
		<Seq>MLKTTKKSLLVFMGVFFLIFGVDQAIKYAILEGFRYESLMIDIVLVFNKG
VAFSLLSFLEGGLKYLQILLILGLFIFLMRQRELFKNHAIEFGMVFGAGV
SNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLKQFFFKQ
KQNKIKA</Seq>
	</Sequence>
	<Topology numTM="4" reliability="91.2252">
		<Region from="1" to="11" loc="I"/>
		<Region from="12" to="27" loc="M"/>
		<Region from="28" to="62" loc="O"/>
		<Region from="63" to="78" loc="M"/>
		<Region from="79" to="90" loc="I"/>
		<Region from="91" to="107" loc="M"/>
		<Region from="108" to="127" loc="O"/>
		<Region from="128" to="143" loc="M"/>
		<Region from="144" to="157" loc="I"/>
	</Topology>
	<Predictions>
		<Prediction name="HMMTOP">
			<Region from="1" to="11" loc="I"/>
			<Region from="12" to="27" loc="M"/>
			<Region from="28" to="62" loc="O"/>
			<Region from="63" to="78" loc="M"/>
			<Region from="79" to="90" loc="I"/>
			<Region from="91" to="107" loc="M"/>
			<Region from="108" to="127" loc="O"/>
			<Region from="128" to="143" loc="M"/>
			<Region from="144" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Memsat">
			<Region from="1" to="10" loc="O"/>
			<Region from="11" to="27" loc="M"/>
			<Region from="28" to="62" loc="I"/>
			<Region from="63" to="79" loc="M"/>
			<Region from="80" to="90" loc="O"/>
			<Region from="91" to="109" loc="M"/>
			<Region from="110" to="125" loc="I"/>
			<Region from="126" to="144" loc="M"/>
			<Region from="145" to="157" loc="O"/>
		</Prediction>
		<Prediction name="Octopus">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="29" loc="M"/>
			<Region from="30" to="49" loc="O"/>
			<Region from="50" to="53" loc="L"/>
			<Region from="54" to="59" loc="O"/>
			<Region from="60" to="80" loc="M"/>
			<Region from="81" to="87" loc="I"/>
			<Region from="88" to="118" loc="M"/>
			<Region from="119" to="125" loc="O"/>
			<Region from="126" to="146" loc="M"/>
			<Region from="147" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Philius">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="31" loc="M"/>
			<Region from="32" to="60" loc="O"/>
			<Region from="61" to="79" loc="M"/>
			<Region from="80" to="87" loc="I"/>
			<Region from="88" to="109" loc="M"/>
			<Region from="110" to="124" loc="O"/>
			<Region from="125" to="148" loc="M"/>
			<Region from="149" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Phobius">
			<Region from="1" to="25" loc="S"/>
			<Region from="26" to="61" loc="O"/>
			<Region from="62" to="79" loc="M"/>
			<Region from="80" to="87" loc="I"/>
			<Region from="88" to="104" loc="M"/>
			<Region from="105" to="123" loc="O"/>
			<Region from="124" to="143" loc="M"/>
			<Region from="144" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Pro">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="58" loc="O"/>
			<Region from="59" to="79" loc="M"/>
			<Region from="80" to="88" loc="I"/>
			<Region from="89" to="109" loc="M"/>
			<Region from="110" to="125" loc="O"/>
			<Region from="126" to="146" loc="M"/>
			<Region from="147" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Prodiv">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="59" loc="O"/>
			<Region from="60" to="80" loc="M"/>
			<Region from="81" to="89" loc="I"/>
			<Region from="90" to="110" loc="M"/>
			<Region from="111" to="126" loc="O"/>
			<Region from="127" to="147" loc="M"/>
			<Region from="148" to="157" loc="I"/>
		</Prediction>
		<Prediction name="Scampi">
			<Region from="1" to="7" loc="I"/>
			<Region from="8" to="28" loc="M"/>
			<Region from="29" to="38" loc="O"/>
			<Region from="39" to="59" loc="M"/>
			<Region from="60" to="64" loc="I"/>
			<Region from="65" to="85" loc="M"/>
			<Region from="86" to="128" loc="O"/>
			<Region from="129" to="149" loc="M"/>
			<Region from="150" to="157" loc="I"/>
		</Prediction>
		<Prediction name="ScampiMsa">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="28" loc="M"/>
			<Region from="29" to="58" loc="O"/>
			<Region from="59" to="78" loc="M"/>
			<Region from="79" to="86" loc="I"/>
			<Region from="87" to="106" loc="M"/>
			<Region from="107" to="126" loc="O"/>
			<Region from="127" to="146" loc="M"/>
			<Region from="147" to="157" loc="I"/>
		</Prediction>
		<Prediction name="TMHMM">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="31" loc="M"/>
			<Region from="32" to="55" loc="O"/>
			<Region from="56" to="78" loc="M"/>
			<Region from="79" to="89" loc="I"/>
			<Region from="90" to="109" loc="M"/>
			<Region from="110" to="123" loc="O"/>
			<Region from="124" to="143" loc="M"/>
			<Region from="144" to="157" loc="I"/>
		</Prediction>
	</Predictions>
	<Constraints>
		<Constraint source="TOPDB" sourceId="AP04547">
			<ConstraintRegion from="10" to="12" loc="I" subId="00001" subSource="5dirA"/>
			<ConstraintRegion from="13" to="27" loc="M" subId="00002" subSource="5dirA"/>
			<ConstraintRegion from="27" to="65" loc="O" subId="00003" subSource="5dirA"/>
			<ConstraintRegion from="66" to="76" loc="M" subId="00004" subSource="5dirA"/>
			<ConstraintRegion from="77" to="90" loc="I" subId="00005" subSource="5dirA"/>
			<ConstraintRegion from="91" to="107" loc="M" subId="00006" subSource="5dirA"/>
			<ConstraintRegion from="108" to="127" loc="O" subId="00007" subSource="5dirA"/>
			<ConstraintRegion from="128" to="143" loc="M" subId="00008" subSource="5dirA"/>
			<ConstraintRegion from="144" to="146" loc="I" subId="00009" subSource="5dirA"/>
		</Constraint>
	</Constraints>
</CCTOPItem>
