<?xml version="1.0"?>
<CCTOPItem id="O61213" transmembrane="yes" evidence="Experiment">
	<Copyright>Copyrighted by the Institute of Enzymology!</Copyright>
	<Name>Dual oxidase 1</Name>
	<CrossRef>
		<UniProt id="DUOX1_CAEEL">
			<AC>O61213</AC>
			<AC>Q9NH90</AC>
		</UniProt>
		<TOPDB id="AP02437">
			<Alignment>
				<CrossRefSeq>MRSKHVLYIAILFSSIFGGKGIQQNEEFQRYDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSVNNSLPSARELSDILFKGESGIPNTRGCTTLLAFFSQVVAYEIMQSNGVSCPLETLKIQVPLCDNVFDKECEGKTEIPFTRAKYDKATGNGLNSPREQINERTSWIDGSFIYGTTQPWVSSLRSFKQGRLAEGVPGYPPLNNPHIPLNNPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIHREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEFRTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAERDDNIVVEDLRDYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGLAPKTWETMNEDFYKKHTAKVEKLKELYGGNILYLDAYVGGMLEGGENGPGELFKEIIKDQFTRIRDGDRFWFENKLNGLFTDEEVQMIHSITLRDIIKATTDIDETMLQKDVFFFKEGDPCPQPFQVNTTGLEPCVPFMQSTYWTDNDTTYVFTLIGLACVPLICYGIGRYLVNRRIAIGHNSACDSLTTDFANDDCGAKGDIYGVNALEWLQEEYIRQVRIEIENTTLAVKKPRGGILRKIRFETGQKIELFHSMPNPSAMHGPFVLLSQKNNHHLVIRLSSDRDLSKFLDQIRQAASGINAEVIIKDEENSILLSQAITKERRQDRLDLFFREAYAKAFNDSELQDSETSFDSSNDDILNETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGVHITESVQLRLFNEVLHYAGVSNDAKYLTYDDFNALFSDIPDKQPVGLPFNRKNYQPSIGETSSLNSFAVVDRSINSSAPLTLIHKVSAFLETYRQHVFIVFCFVAINLVLFFERFWHYRYMAENRDLRRVMGAGIAITRGAAGALSFCMALILLTVCRNIITLLRETVIAQYIPFDSAIAFHKIVALFAAFWATLHTVGHCVNFYHVGTQSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALVAVMCIIYVFALPCFIKRAYHAFRLTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVLFVIDRIIGLMQYYKKLEIVNAEILPSDIIYIEYRRPREFKYKSGQWVTVSSPSISCTFNESHAFSIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTGSPFPLIHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSSDSFHRVRCRKVYFLWVCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQTFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSKIGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF</CrossRefSeq>
				<OrigSeq>MRSKHVLYIAILFSSIFGGKGIQQNEEFQRYDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSVNNSLPSARELSDILFKGESGIPNTRGCTTLLAFFSQVVAYEIMQSNGVSCPLETLKIQVPLCDNVFDKECEGKTEIPFTRAKYDKATGNGLNSPREQINERTSWIDGSFIYGTTQPWVSSLRSFKQGRLAEGVPGYPPLNNPHIPLNNPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIHREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEFRTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAERDDNIVVEDLRDYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGLAPKTWETMNEDFYKKHTAKVEKLKELYGGNILYLDAYVGGMLEGGENGPGELFKEIIKDQFTRIRDGDRFWFENKLNGLFTDEEVQMIHSITLRDIIKATTDIDETMLQKDVFFFKEGDPCPQPFQVNTTGLEPCVPFMQSTYWTDNDTTYVFTLIGLACVPLICYGIGRYLVNRRIAIGHNSACDSLTTDFANDDCGAKGDIYGVNALEWLQEEYIRQVRIEIENTTLAVKKPRGGILRKIRFETGQKIELFHSMPNPSAMHGPFVLLSQKNNHHLVIRLSSDRDLSKFLDQIRQAASGINAEVIIKDEENSILLSQAITKERRQDRLDLFFREAYAKAFNDSELQDSETSFDSSNDDILNETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGVHITESVQLRLFNEVLHYAGVSNDAKYLTYDDFNALFSDIPDKQPVGLPFNRKNYQPSIGETSSLNSFAVVDRSINSSAPLTLIHKVSAFLETYRQHVFIVFCFVAINLVLFFERFWHYRYMAENRDLRRVMGAGIAITRGAAGALSFCMALILLTVCRNIITLLRETVIAQYIPFDSAIAFHKIVALFAAFWATLHTVGHCVNFYHVGTQSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALVAVMCIIYVFALPCFIKRAYHAFRLTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVLFVIDRIIGLMQYYKKLEIVNAEILPSDIIYIEYRRPREFKYKSGQWVTVSSPSISCTFNESHAFSIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTGSPFPLIHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSSDSFHRVRCRKVYFLWVCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQTFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSKIGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF</OrigSeq>
			</Alignment>
		</TOPDB>
		<Signal id="TopDB-AP02437">
			<Results>1-21</Results>
		</Signal>
		<Signal id="SignalP">
			<Results>1-22</Results>
			<Parameters>0.999622</Parameters>
		</Signal>
	</CrossRef>
	<Sequence length="1497" checkSum="8deeb81ebdad87f73a5e1630244a0e2c">
		<Signal from="1" to="21"/>
		<Seq>MRSKHVLYIAILFSSIFGGKGIQQNEEFQRYDGWYNNLANSEWGSAGSRL
HRDARSYYSDGVYSVNNSLPSARELSDILFKGESGIPNTRGCTTLLAFFS
QVVAYEIMQSNGVSCPLETLKIQVPLCDNVFDKECEGKTEIPFTRAKYDK
ATGNGLNSPREQINERTSWIDGSFIYGTTQPWVSSLRSFKQGRLAEGVPG
YPPLNNPHIPLNNPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILF
RWHNYNANQIHREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGED
VRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEFRT
EVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAERDDNIVVEDLR
DYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGLAPKTWETMNED
FYKKHTAKVEKLKELYGGNILYLDAYVGGMLEGGENGPGELFKEIIKDQF
TRIRDGDRFWFENKLNGLFTDEEVQMIHSITLRDIIKATTDIDETMLQKD
VFFFKEGDPCPQPFQVNTTGLEPCVPFMQSTYWTDNDTTYVFTLIGLACV
PLICYGIGRYLVNRRIAIGHNSACDSLTTDFANDDCGAKGDIYGVNALEW
LQEEYIRQVRIEIENTTLAVKKPRGGILRKIRFETGQKIELFHSMPNPSA
MHGPFVLLSQKNNHHLVIRLSSDRDLSKFLDQIRQAASGINAEVIIKDEE
NSILLSQAITKERRQDRLDLFFREAYAKAFNDSELQDSETSFDSSNDDIL
NETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFV
NAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGVHITESVQLR
LFNEVLHYAGVSNDAKYLTYDDFNALFSDIPDKQPVGLPFNRKNYQPSIG
ETSSLNSFAVVDRSINSSAPLTLIHKVSAFLETYRQHVFIVFCFVAINLV
LFFERFWHYRYMAENRDLRRVMGAGIAITRGAAGALSFCMALILLTVCRN
IITLLRETVIAQYIPFDSAIAFHKIVALFAAFWATLHTVGHCVNFYHVGT
QSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALVAVMCIIYVFA
LPCFIKRAYHAFRLTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVL
FVIDRIIGLMQYYKKLEIVNAEILPSDIIYIEYRRPREFKYKSGQWVTVS
SPSISCTFNESHAFSIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTG
SPFPLIHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSS
DSFHRVRCRKVYFLWVCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQ
TFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFI
QSEHKEQSKIGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF</Seq>
	</Sequence>
	<Topology numTM="7" reliability="85.0202">
		<Region from="1" to="21" loc="S"/>
		<Region from="22" to="589" loc="O"/>
		<Region from="590" to="611" loc="M"/>
		<Region from="612" to="987" loc="I"/>
		<Region from="988" to="1003" loc="M"/>
		<Region from="1004" to="1026" loc="O"/>
		<Region from="1027" to="1048" loc="M"/>
		<Region from="1049" to="1074" loc="I"/>
		<Region from="1075" to="1090" loc="M"/>
		<Region from="1091" to="1130" loc="O"/>
		<Region from="1131" to="1150" loc="M"/>
		<Region from="1151" to="1160" loc="I"/>
		<Region from="1161" to="1181" loc="M"/>
		<Region from="1182" to="1191" loc="O"/>
		<Region from="1192" to="1207" loc="M"/>
		<Region from="1208" to="1497" loc="I"/>
	</Topology>
	<Predictions>
		<Prediction name="HMMTOP">
			<Region from="22" to="591" loc="O"/>
			<Region from="592" to="613" loc="M"/>
			<Region from="614" to="987" loc="I"/>
			<Region from="988" to="1003" loc="M"/>
			<Region from="1004" to="1023" loc="O"/>
			<Region from="1024" to="1045" loc="M"/>
			<Region from="1046" to="1075" loc="I"/>
			<Region from="1076" to="1100" loc="M"/>
			<Region from="1101" to="1130" loc="O"/>
			<Region from="1131" to="1154" loc="M"/>
			<Region from="1155" to="1169" loc="I"/>
			<Region from="1170" to="1185" loc="M"/>
			<Region from="1186" to="1193" loc="O"/>
			<Region from="1194" to="1212" loc="L"/>
			<Region from="1213" to="1497" loc="O"/>
		</Prediction>
		<Prediction name="Memsat">
			<Region from="22" to="588" loc="O"/>
			<Region from="589" to="610" loc="M"/>
			<Region from="611" to="987" loc="I"/>
			<Region from="988" to="1006" loc="M"/>
			<Region from="1007" to="1021" loc="O"/>
			<Region from="1022" to="1052" loc="M"/>
			<Region from="1053" to="1072" loc="I"/>
			<Region from="1073" to="1096" loc="M"/>
			<Region from="1097" to="1126" loc="O"/>
			<Region from="1127" to="1150" loc="M"/>
			<Region from="1151" to="1163" loc="I"/>
			<Region from="1164" to="1182" loc="M"/>
			<Region from="1183" to="1191" loc="O"/>
			<Region from="1192" to="1207" loc="M"/>
			<Region from="1208" to="1324" loc="I"/>
			<Region from="1325" to="1340" loc="M"/>
			<Region from="1341" to="1497" loc="O"/>
		</Prediction>
		<Prediction name="Octopus">
			<Region from="22" to="588" loc="O"/>
			<Region from="589" to="609" loc="M"/>
			<Region from="610" to="985" loc="I"/>
			<Region from="986" to="1006" loc="M"/>
			<Region from="1007" to="1021" loc="O"/>
			<Region from="1022" to="1052" loc="M"/>
			<Region from="1053" to="1072" loc="I"/>
			<Region from="1073" to="1093" loc="M"/>
			<Region from="1094" to="1128" loc="O"/>
			<Region from="1129" to="1149" loc="M"/>
			<Region from="1150" to="1159" loc="I"/>
			<Region from="1160" to="1180" loc="M"/>
			<Region from="1181" to="1193" loc="O"/>
			<Region from="1194" to="1199" loc="L"/>
			<Region from="1200" to="1321" loc="O"/>
			<Region from="1322" to="1342" loc="M"/>
			<Region from="1343" to="1497" loc="I"/>
		</Prediction>
		<Prediction name="Philius">
			<Region from="22" to="588" loc="O"/>
			<Region from="589" to="612" loc="M"/>
			<Region from="613" to="986" loc="I"/>
			<Region from="987" to="1007" loc="M"/>
			<Region from="1008" to="1025" loc="O"/>
			<Region from="1026" to="1052" loc="M"/>
			<Region from="1053" to="1069" loc="I"/>
			<Region from="1070" to="1090" loc="M"/>
			<Region from="1091" to="1124" loc="O"/>
			<Region from="1125" to="1151" loc="M"/>
			<Region from="1152" to="1161" loc="I"/>
			<Region from="1162" to="1181" loc="M"/>
			<Region from="1182" to="1189" loc="O"/>
			<Region from="1190" to="1209" loc="M"/>
			<Region from="1210" to="1497" loc="I"/>
		</Prediction>
		<Prediction name="Phobius">
			<Region from="22" to="589" loc="O"/>
			<Region from="590" to="612" loc="M"/>
			<Region from="613" to="987" loc="I"/>
			<Region from="988" to="1007" loc="M"/>
			<Region from="1008" to="1026" loc="O"/>
			<Region from="1027" to="1052" loc="M"/>
			<Region from="1053" to="1063" loc="I"/>
			<Region from="1064" to="1086" loc="M"/>
			<Region from="1087" to="1124" loc="O"/>
			<Region from="1125" to="1149" loc="M"/>
			<Region from="1150" to="1160" loc="I"/>
			<Region from="1161" to="1178" loc="M"/>
			<Region from="1179" to="1189" loc="O"/>
			<Region from="1190" to="1207" loc="M"/>
			<Region from="1208" to="1497" loc="I"/>
		</Prediction>
		<Prediction name="Pro">
			<Region from="22" to="986" loc="I"/>
			<Region from="987" to="1007" loc="M"/>
			<Region from="1008" to="1027" loc="O"/>
			<Region from="1028" to="1048" loc="M"/>
			<Region from="1049" to="1068" loc="I"/>
			<Region from="1069" to="1089" loc="M"/>
			<Region from="1090" to="1130" loc="O"/>
			<Region from="1131" to="1151" loc="M"/>
			<Region from="1152" to="1160" loc="I"/>
			<Region from="1161" to="1181" loc="M"/>
			<Region from="1182" to="1320" loc="O"/>
			<Region from="1321" to="1341" loc="M"/>
			<Region from="1342" to="1497" loc="I"/>
		</Prediction>
		<Prediction name="Prodiv">
			<Region from="22" to="584" loc="O"/>
			<Region from="585" to="605" loc="M"/>
			<Region from="606" to="986" loc="I"/>
			<Region from="987" to="1007" loc="M"/>
			<Region from="1008" to="1027" loc="O"/>
			<Region from="1028" to="1048" loc="M"/>
			<Region from="1049" to="1068" loc="I"/>
			<Region from="1069" to="1089" loc="M"/>
			<Region from="1090" to="1130" loc="O"/>
			<Region from="1131" to="1151" loc="M"/>
			<Region from="1152" to="1162" loc="I"/>
			<Region from="1163" to="1183" loc="M"/>
			<Region from="1184" to="1497" loc="O"/>
		</Prediction>
		<Prediction name="Scampi">
			<Region from="22" to="87" loc="I"/>
			<Region from="88" to="108" loc="M"/>
			<Region from="109" to="587" loc="O"/>
			<Region from="588" to="608" loc="M"/>
			<Region from="609" to="986" loc="I"/>
			<Region from="987" to="1007" loc="M"/>
			<Region from="1008" to="1027" loc="O"/>
			<Region from="1028" to="1048" loc="M"/>
			<Region from="1049" to="1065" loc="I"/>
			<Region from="1066" to="1086" loc="M"/>
			<Region from="1087" to="1130" loc="O"/>
			<Region from="1131" to="1151" loc="M"/>
			<Region from="1152" to="1157" loc="I"/>
			<Region from="1158" to="1178" loc="M"/>
			<Region from="1179" to="1189" loc="O"/>
			<Region from="1190" to="1210" loc="M"/>
			<Region from="1211" to="1318" loc="I"/>
			<Region from="1319" to="1339" loc="M"/>
			<Region from="1340" to="1497" loc="O"/>
		</Prediction>
		<Prediction name="ScampiMsa">
			<Region from="22" to="591" loc="O"/>
			<Region from="592" to="611" loc="M"/>
			<Region from="612" to="987" loc="I"/>
			<Region from="988" to="1007" loc="M"/>
			<Region from="1008" to="1034" loc="O"/>
			<Region from="1035" to="1054" loc="M"/>
			<Region from="1055" to="1074" loc="I"/>
			<Region from="1075" to="1094" loc="M"/>
			<Region from="1095" to="1130" loc="O"/>
			<Region from="1131" to="1150" loc="M"/>
			<Region from="1151" to="1160" loc="I"/>
			<Region from="1161" to="1180" loc="M"/>
			<Region from="1181" to="1188" loc="O"/>
			<Region from="1189" to="1208" loc="M"/>
			<Region from="1209" to="1321" loc="I"/>
			<Region from="1322" to="1341" loc="M"/>
			<Region from="1342" to="1497" loc="O"/>
		</Prediction>
		<Prediction name="TMHMM">
			<Region from="22" to="589" loc="O"/>
			<Region from="590" to="612" loc="M"/>
			<Region from="613" to="987" loc="I"/>
			<Region from="988" to="1006" loc="M"/>
			<Region from="1007" to="1025" loc="O"/>
			<Region from="1026" to="1048" loc="M"/>
			<Region from="1049" to="1068" loc="I"/>
			<Region from="1069" to="1091" loc="M"/>
			<Region from="1092" to="1128" loc="O"/>
			<Region from="1129" to="1151" loc="M"/>
			<Region from="1152" to="1157" loc="I"/>
			<Region from="1158" to="1180" loc="M"/>
			<Region from="1181" to="1189" loc="O"/>
			<Region from="1190" to="1209" loc="M"/>
			<Region from="1210" to="1497" loc="I"/>
		</Prediction>
	</Predictions>
	<Constraints>
		<Constraint source="SIGNAL" sourceId="TopDB-AP02437">
			<ConstraintRegion from="22" to="22" loc="O"/>
		</Constraint>
		<Constraint source="TOPDB" sourceId="AP02437">
			<ConstraintRegion from="66" to="66" loc="O" subId="00001" subSource="17761667"/>
		</Constraint>
	</Constraints>
</CCTOPItem>
