<?xml version="1.0"?>
<CCTOPItem id="P21589" transmembrane="yes" evidence="Experiment">
	<Copyright>Copyrighted by the Institute of Enzymology!</Copyright>
	<Name>5'-nucleotidase</Name>
	<CrossRef>
		<UniProt id="5NTD_HUMAN">
			<AC>P21589</AC>
			<AC>B3KQI8</AC>
			<AC>O75520</AC>
			<AC>Q5W116</AC>
		</UniProt>
		<PDB id="4h1s">
			<Chain id="A"/>
			<Chain id="B"/>
		</PDB>
		<PDB id="4h1y">
			<Chain id="P"/>
		</PDB>
		<PDB id="4h2b">
			<Chain id="A"/>
		</PDB>
		<PDB id="4h2f">
			<Chain id="A"/>
		</PDB>
		<PDB id="4h2g">
			<Chain id="A"/>
		</PDB>
		<PDB id="4h2i">
			<Chain id="A"/>
		</PDB>
		<TOPDB id="AB02087">
			<Alignment>
				<CrossRefSeq>MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ</CrossRefSeq>
				<OrigSeq>MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ</OrigSeq>
			</Alignment>
		</TOPDB>
		<Signal id="TopDB-AB02087">
			<Results>1-26</Results>
		</Signal>
		<Signal id="SignalP">
			<Results>1-27</Results>
			<Parameters>0.999706</Parameters>
		</Signal>
	</CrossRef>
	<Sequence length="574" checkSum="bbe8de5bb29ba879cb7b0b37bf678985">
		<Signal from="1" to="26"/>
		<Seq>MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSK
CVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAE
VAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPL
ASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITAL
QPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYT
GNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSS
QSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDE
RNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFL
QVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNF
LANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFST
GSHCHGSFSLIFLSLWAVIFVLYQ</Seq>
	</Sequence>
	<Topology numTM="1" reliability="97.0123">
		<Region from="1" to="26" loc="S"/>
		<Region from="27" to="552" loc="O"/>
		<Region from="553" to="573" loc="M"/>
		<Region from="574" to="574" loc="I"/>
	</Topology>
	<Predictions>
		<Prediction name="Memsat">
			<Region from="27" to="554" loc="I"/>
			<Region from="555" to="571" loc="M"/>
			<Region from="572" to="574" loc="O"/>
		</Prediction>
		<Prediction name="Octopus">
			<Region from="27" to="552" loc="I"/>
			<Region from="553" to="573" loc="M"/>
			<Region from="574" to="574" loc="O"/>
		</Prediction>
		<Prediction name="Philius">
			<Region from="27" to="552" loc="O"/>
			<Region from="553" to="573" loc="M"/>
			<Region from="574" to="574" loc="I"/>
		</Prediction>
		<Prediction name="Phobius">
			<Region from="27" to="554" loc="O"/>
			<Region from="555" to="573" loc="M"/>
			<Region from="574" to="574" loc="I"/>
		</Prediction>
		<Prediction name="Pro">
			<Region from="27" to="552" loc="I"/>
			<Region from="553" to="573" loc="M"/>
			<Region from="574" to="574" loc="O"/>
		</Prediction>
		<Prediction name="Prodiv">
			<Region from="27" to="550" loc="I"/>
			<Region from="551" to="571" loc="M"/>
			<Region from="572" to="574" loc="O"/>
		</Prediction>
		<Prediction name="Scampi">
			<Region from="27" to="552" loc="I"/>
			<Region from="553" to="573" loc="M"/>
			<Region from="574" to="574" loc="O"/>
		</Prediction>
		<Prediction name="ScampiMsa">
			<Region from="27" to="552" loc="I"/>
			<Region from="553" to="572" loc="M"/>
			<Region from="573" to="574" loc="O"/>
		</Prediction>
		<Prediction name="TMHMM">
			<Region from="27" to="555" loc="O"/>
			<Region from="556" to="573" loc="M"/>
			<Region from="574" to="574" loc="I"/>
		</Prediction>
	</Predictions>
	<Constraints>
		<Constraint source="SIGNAL" sourceId="TopDB-AB02087">
			<ConstraintRegion from="27" to="27" loc="O"/>
		</Constraint>
		<Constraint source="TOPDB" sourceId="AB02087">
			<ConstraintRegion from="27" to="549" loc="O" subId="00006" subSource="4h1sA"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00007" subSource="4h1sB"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00008" subSource="4h1yP"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00009" subSource="4h2bA"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00010" subSource="4h2fA"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00011" subSource="4h2gA"/>
			<ConstraintRegion from="27" to="549" loc="O" subId="00012" subSource="4h2iA"/>
			<ConstraintRegion from="311" to="311" loc="O" subId="00001" subSource="19159218"/>
			<ConstraintRegion from="311" to="311" loc="O" subId="00002" subSource="23142347"/>
			<ConstraintRegion from="333" to="333" loc="O" subId="00003" subSource="19159218"/>
			<ConstraintRegion from="333" to="333" loc="O" subId="00004" subSource="19349973"/>
			<ConstraintRegion from="403" to="403" loc="O" subId="00005" subSource="19159218"/>
		</Constraint>
	</Constraints>
</CCTOPItem>
