<?xml version="1.0"?>
<CCTOPItem id="Q25605" transmembrane="yes" evidence="Experiment">
	<Copyright>Copyrighted by the Institute of Enzymology!</Copyright>
	<Name>Excitatory amino acid transporter</Name>
	<CrossRef>
		<UniProt id="EAAT_ONCVO">
			<AC>Q25605</AC>
		</UniProt>
		<TOPDB id="AP02686">
			<Alignment>
				<CrossRefSeq>MVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGTGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASVEYTSGMNVLGVIVFCIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGIFCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFMRGLFQAWITALGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSKADLDAHDRLAATTRSHSIAMNDEKRQLAVYNSLPTDDEKHTH</CrossRefSeq>
				<OrigSeq>MVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGTGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASVEYTSGMNVLGVIVFCIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGILCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFMRGLFQAWITGLGTASSSDTLPITYICLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSKADLDAHDRLAATTRSHSIAMNDEKRQLAVYNSLPTDDEKHTH</OrigSeq>
			</Alignment>
		</TOPDB>
		<TOPDB id="AP02421">
			<Alignment>
				<CrossRefSeq>--SFFRRHALVLLTVSGVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETVDSFLDLLRNLFPSNLVVAAFTTSATDY-----TVVTHNTSS-------GNVTKEKIPVVTDVEGMNILGLVLFALVLGVALKKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIVEMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLSLILAVDWIVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQEVKVEAIPNSKSEEE-----------------</CrossRefSeq>
				<OrigSeq>MVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGD--PTIKKEI----GTGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASV-EYTSGMNVLGVIVFCIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGILCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFMRGLFQAWITGLGTASSSDTLPITYICLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSKADLDAHDRLAATTRSHSIAMNDEKRQQLAVYNSLPTDDEKHTH</OrigSeq>
			</Alignment>
		</TOPDB>
		<TOPDB id="AP02122">
			<Alignment>
				<CrossRefSeq>---FLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDY-----KVVTQNSSS-------GNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEE-----------------</CrossRefSeq>
				<OrigSeq>MVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGD--PTIKK-EIG---TGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASV-EYTSGMNVLGVIVFCIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGILCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFMRGLFQAWITGLGTASSSDTLPITYICLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSKADLDAHDRLAATTRSHSIAMNDEKRQQLAVYNSLPTDDEKHTH</OrigSeq>
			</Alignment>
		</TOPDB>
	</CrossRef>
	<Sequence length="492" checkSum="d034e3efd53021f2a9df2cd73fa8f132">
		<Seq>MVSWIRKNLLLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMH
MLKMMILPLIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIF
LVLVIHPGDPTIKKEIGTGTEGKTVSTVDTLLDLLRNMFPENVVQATFQQ
VQTKYIKVRPKVVKNNDSATLAALNNGSLDYVKASVEYTSGMNVLGVIVF
CIAIGISLSQLGQEAHVMVQFFVIMDKVIMKLVMTVMWYSPFGILCLIMG
KILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFVTTKKNPYVFM
RGLFQAWITGLGTASSSDTLPITYICLEENLGVDRRVTRFVLPVGATINM
DGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLV
TMLLVLTAVGLPVKDVSLIVAVDWLLDRIRTSINVLGDAMGAGIVYHYSK
ADLDAHDRLAATTRSHSIAMNDEKRQLAVYNSLPTDDEKHTH</Seq>
	</Sequence>
	<Topology numTM="8" reliability="80.6818">
		<Region from="1" to="8" loc="I"/>
		<Region from="9" to="29" loc="M"/>
		<Region from="30" to="50" loc="O"/>
		<Region from="51" to="71" loc="M"/>
		<Region from="72" to="82" loc="I"/>
		<Region from="83" to="103" loc="M"/>
		<Region from="104" to="190" loc="O"/>
		<Region from="191" to="211" loc="M"/>
		<Region from="212" to="231" loc="I"/>
		<Region from="232" to="253" loc="M"/>
		<Region from="254" to="264" loc="O"/>
		<Region from="265" to="290" loc="M"/>
		<Region from="291" to="349" loc="I"/>
		<Region from="350" to="370" loc="M"/>
		<Region from="371" to="383" loc="O"/>
		<Region from="384" to="411" loc="M"/>
		<Region from="412" to="492" loc="I"/>
	</Topology>
	<Predictions>
		<Prediction name="HMMTOP">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="30" loc="M"/>
			<Region from="31" to="33" loc="O"/>
			<Region from="34" to="52" loc="L"/>
			<Region from="53" to="55" loc="O"/>
			<Region from="56" to="77" loc="M"/>
			<Region from="78" to="80" loc="I"/>
			<Region from="81" to="102" loc="M"/>
			<Region from="103" to="191" loc="O"/>
			<Region from="192" to="213" loc="M"/>
			<Region from="214" to="216" loc="I"/>
			<Region from="217" to="238" loc="M"/>
			<Region from="239" to="241" loc="O"/>
			<Region from="242" to="262" loc="M"/>
			<Region from="263" to="265" loc="I"/>
			<Region from="266" to="287" loc="M"/>
			<Region from="288" to="290" loc="O"/>
			<Region from="291" to="309" loc="L"/>
			<Region from="310" to="312" loc="O"/>
			<Region from="313" to="331" loc="L"/>
			<Region from="332" to="334" loc="O"/>
			<Region from="335" to="353" loc="L"/>
			<Region from="354" to="356" loc="O"/>
			<Region from="357" to="375" loc="L"/>
			<Region from="376" to="378" loc="O"/>
			<Region from="379" to="397" loc="L"/>
			<Region from="398" to="400" loc="O"/>
			<Region from="401" to="422" loc="M"/>
			<Region from="423" to="492" loc="I"/>
		</Prediction>
		<Prediction name="Memsat">
			<Region from="1" to="10" loc="I"/>
			<Region from="11" to="28" loc="M"/>
			<Region from="29" to="40" loc="O"/>
			<Region from="41" to="61" loc="M"/>
			<Region from="62" to="80" loc="I"/>
			<Region from="81" to="104" loc="M"/>
			<Region from="105" to="192" loc="O"/>
			<Region from="193" to="208" loc="M"/>
			<Region from="209" to="235" loc="I"/>
			<Region from="236" to="258" loc="M"/>
			<Region from="259" to="261" loc="O"/>
			<Region from="262" to="292" loc="M"/>
			<Region from="293" to="295" loc="I"/>
			<Region from="296" to="324" loc="L"/>
			<Region from="325" to="339" loc="I"/>
			<Region from="340" to="359" loc="M"/>
			<Region from="360" to="362" loc="O"/>
			<Region from="363" to="397" loc="L"/>
			<Region from="398" to="400" loc="O"/>
			<Region from="401" to="419" loc="M"/>
			<Region from="420" to="423" loc="I"/>
			<Region from="424" to="441" loc="M"/>
			<Region from="442" to="492" loc="O"/>
		</Prediction>
		<Prediction name="Octopus">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="49" loc="O"/>
			<Region from="50" to="70" loc="M"/>
			<Region from="71" to="82" loc="I"/>
			<Region from="83" to="103" loc="M"/>
			<Region from="104" to="190" loc="O"/>
			<Region from="191" to="211" loc="M"/>
			<Region from="212" to="229" loc="I"/>
			<Region from="230" to="250" loc="M"/>
			<Region from="251" to="264" loc="O"/>
			<Region from="265" to="285" loc="M"/>
			<Region from="286" to="343" loc="I"/>
			<Region from="344" to="364" loc="M"/>
			<Region from="365" to="376" loc="O"/>
			<Region from="377" to="397" loc="M"/>
			<Region from="398" to="398" loc="I"/>
			<Region from="399" to="419" loc="M"/>
			<Region from="420" to="492" loc="O"/>
		</Prediction>
		<Prediction name="Philius">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="31" loc="M"/>
			<Region from="32" to="48" loc="O"/>
			<Region from="49" to="71" loc="M"/>
			<Region from="72" to="82" loc="I"/>
			<Region from="83" to="105" loc="M"/>
			<Region from="106" to="190" loc="O"/>
			<Region from="191" to="212" loc="M"/>
			<Region from="213" to="231" loc="I"/>
			<Region from="232" to="253" loc="M"/>
			<Region from="254" to="264" loc="O"/>
			<Region from="265" to="290" loc="M"/>
			<Region from="291" to="344" loc="I"/>
			<Region from="345" to="375" loc="M"/>
			<Region from="376" to="381" loc="O"/>
			<Region from="382" to="411" loc="M"/>
			<Region from="412" to="492" loc="I"/>
		</Prediction>
		<Prediction name="Phobius">
			<Region from="1" to="24" loc="S"/>
			<Region from="25" to="47" loc="O"/>
			<Region from="48" to="71" loc="M"/>
			<Region from="72" to="82" loc="I"/>
			<Region from="83" to="105" loc="M"/>
			<Region from="106" to="190" loc="O"/>
			<Region from="191" to="211" loc="M"/>
			<Region from="212" to="231" loc="I"/>
			<Region from="232" to="253" loc="M"/>
			<Region from="254" to="264" loc="O"/>
			<Region from="265" to="291" loc="M"/>
			<Region from="292" to="492" loc="I"/>
		</Prediction>
		<Prediction name="Pro">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="50" loc="O"/>
			<Region from="51" to="71" loc="M"/>
			<Region from="72" to="82" loc="I"/>
			<Region from="83" to="103" loc="M"/>
			<Region from="104" to="187" loc="O"/>
			<Region from="188" to="208" loc="M"/>
			<Region from="209" to="228" loc="I"/>
			<Region from="229" to="249" loc="M"/>
			<Region from="250" to="269" loc="O"/>
			<Region from="270" to="290" loc="M"/>
			<Region from="291" to="373" loc="I"/>
			<Region from="374" to="394" loc="M"/>
			<Region from="395" to="398" loc="O"/>
			<Region from="399" to="419" loc="M"/>
			<Region from="420" to="492" loc="I"/>
		</Prediction>
		<Prediction name="Prodiv">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="50" loc="O"/>
			<Region from="51" to="71" loc="M"/>
			<Region from="72" to="80" loc="I"/>
			<Region from="81" to="101" loc="M"/>
			<Region from="102" to="191" loc="O"/>
			<Region from="192" to="212" loc="M"/>
			<Region from="213" to="232" loc="I"/>
			<Region from="233" to="253" loc="M"/>
			<Region from="254" to="258" loc="O"/>
			<Region from="259" to="279" loc="M"/>
			<Region from="280" to="349" loc="I"/>
			<Region from="350" to="370" loc="M"/>
			<Region from="371" to="390" loc="O"/>
			<Region from="391" to="411" loc="M"/>
			<Region from="412" to="492" loc="I"/>
		</Prediction>
		<Prediction name="Scampi">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="29" loc="M"/>
			<Region from="30" to="50" loc="O"/>
			<Region from="51" to="71" loc="M"/>
			<Region from="72" to="84" loc="I"/>
			<Region from="85" to="105" loc="M"/>
			<Region from="106" to="190" loc="O"/>
			<Region from="191" to="211" loc="M"/>
			<Region from="212" to="232" loc="I"/>
			<Region from="233" to="253" loc="M"/>
			<Region from="254" to="271" loc="O"/>
			<Region from="272" to="292" loc="M"/>
			<Region from="293" to="353" loc="I"/>
			<Region from="354" to="374" loc="M"/>
			<Region from="375" to="390" loc="O"/>
			<Region from="391" to="411" loc="M"/>
			<Region from="412" to="492" loc="I"/>
		</Prediction>
		<Prediction name="ScampiMsa">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="28" loc="M"/>
			<Region from="29" to="50" loc="O"/>
			<Region from="51" to="70" loc="M"/>
			<Region from="71" to="83" loc="I"/>
			<Region from="84" to="103" loc="M"/>
			<Region from="104" to="187" loc="O"/>
			<Region from="188" to="207" loc="M"/>
			<Region from="208" to="234" loc="I"/>
			<Region from="235" to="254" loc="M"/>
			<Region from="255" to="271" loc="O"/>
			<Region from="272" to="291" loc="M"/>
			<Region from="292" to="347" loc="I"/>
			<Region from="348" to="367" loc="M"/>
			<Region from="368" to="373" loc="O"/>
			<Region from="374" to="393" loc="M"/>
			<Region from="394" to="398" loc="I"/>
			<Region from="399" to="418" loc="M"/>
			<Region from="419" to="492" loc="O"/>
		</Prediction>
		<Prediction name="TMHMM">
			<Region from="1" to="8" loc="I"/>
			<Region from="9" to="31" loc="M"/>
			<Region from="32" to="45" loc="O"/>
			<Region from="46" to="68" loc="M"/>
			<Region from="69" to="80" loc="I"/>
			<Region from="81" to="103" loc="M"/>
			<Region from="104" to="188" loc="O"/>
			<Region from="189" to="211" loc="M"/>
			<Region from="212" to="231" loc="I"/>
			<Region from="232" to="253" loc="M"/>
			<Region from="254" to="267" loc="O"/>
			<Region from="268" to="290" loc="M"/>
			<Region from="291" to="351" loc="I"/>
			<Region from="352" to="374" loc="M"/>
			<Region from="375" to="388" loc="O"/>
			<Region from="389" to="411" loc="M"/>
			<Region from="412" to="492" loc="I"/>
		</Prediction>
	</Predictions>
	<Constraints>
		<Constraint source="TOPDB" sourceId="AP02686">
			<ConstraintRegion from="166" to="166" loc="O" subId="00001" subSource="15888633"/>
			<ConstraintRegion from="176" to="176" loc="O" subId="00002" subSource="15888633"/>
		</Constraint>
		<Constraint source="TOPDB" sourceId="AP02421">
			<ConstraintRegion from="137" to="137" loc="O" subId="00001" subSource="19656770"/>
			<ConstraintRegion from="166" to="166" loc="O" subId="00003" subSource="19656770"/>
			<ConstraintRegion from="166" to="166" loc="O" subId="00004" subSource="19349973"/>
			<ConstraintRegion from="178" to="178" loc="O" subId="00005" subSource="19656770"/>
			<ConstraintRegion from="178" to="178" loc="O" subId="00006" subSource="19349973"/>
		</Constraint>
		<Constraint source="TOPDB" sourceId="AP02122">
			<ConstraintRegion from="166" to="166" loc="O" subId="00001" subSource="19349973"/>
			<ConstraintRegion from="178" to="178" loc="O" subId="00002" subSource="19349973"/>
		</Constraint>
	</Constraints>
</CCTOPItem>
