Copyrighted by the Institute of Enzymology! Alpha-1B adrenergic receptor P15823 Q63215 -------GNNTTSPP-----------APFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR---------------------------------------------------------------------------------------------------------------------------------------------------- MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNST-LPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKE-CGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA----KRTTKNLEA-------------------------------------------GVMKEMSNSKEL-TLRIHSKNFHEDTLSSTKAKGHNP-----------RSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFI-ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQ-CRRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF ------------------------------------MPIMGSSVYITVEL---AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST-GFCAACH-GCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI--CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQME----------------------------SQPLPGERARSTL-------QKEVHAAKSLAIIVGLFALCWLPLHII----NCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII-------RSHVLRQQ--------EPFKAAGTSARVLAAHGS--------DGEQVSLRLNGHPPGVWANGSAP------HPERRPNGYALGLVSGGSAQESQGNTGLPDV-ELLSHELKGVCPEPPGLDDPLAQDGAGVS---------------------- MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVT--RRKAILALLSVWVLSTVISIGPLLGWK-----EPAPNDDKECG----------VTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP-----PDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALL-------SLPEPPGRRGRLDSGPLFTFKLLGD-PESPGTEGDTSNGGCDTTTTDLANGQPGFKSNMPLAPGHF -------------------VRHYNYTGKLNISAD---------KENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG---VAYTANLLLSGATTYKLTPAQWFLREGSMFVAL---------SASVFSLLAIAIERYITM-LKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWN--CISALSSCSTVLPLYHKHYILFCT-TVFTLLLLSIVILYCRIYSLVR--------------TRSRRLTFR---KNISKASRSSEK--------SLAL-----------LKTVIIVLSVFIACWAPLFILLLL-DVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFK---------RPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSS------------------------------------------------------------------------------------------------------ MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFIL---FAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLG---------YWVL--GRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVT---EEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWL--GYFNSCLNPIIYPCSSKEFKRAFMRILG-CQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQS------RKDSLDDSGSCMSGGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGL VLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLP FSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYS LQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEE PFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKE LTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPC SSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQS RKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGAL LSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANG QPGFKSNMPLAPGHF