<?xml version="1.0"?>
<CCTOPItem id="P16237" transmembrane="yes" evidence="Prediction">
	<Copyright>Copyrighted by the Institute of Enzymology!</Copyright>
	<Name>3-hydroxy-3-methylglutaryl-coenzyme A reductase</Name>
	<CrossRef>
		<UniProt id="HMDH_SCHMA">
			<AC>P16237</AC>
		</UniProt>
	</CrossRef>
	<Sequence length="948" checkSum="f2c7796145146048bcd577a7771efdbb">
		<Seq>MLKILNTVLLFFDCFSTGTFFVLLIYLFTRLRTHLLHFSSSNCHLDVIIY
QSRAVIIFLVVFVYFIGVLTCKINDKILVHTMLRNKRQLNTLFYTLILFT
FALCSLSSVLFVPYTSFAIFLLSTSVFLLFSDLSVFFIVLEYYLLEIELV
NYEHAKRHCLLSHLFSNQLFVDHMLGMFLKTSLFSISTTSKYAYLESIFK
CTLMEQIIYIMIVFVFLPSFMRIFASYAKRMYGEQKKCLVSNKGVSSSTR
KRRHSYSSGHSYVEYRRMSVHNLIGYVVNPNCHYKCWSTTFVIFVSLIIL
HLNNRYSERISSFKHNSSENEVFPVLYHITAYEVTSIFHFIYNIFHVINA
NLVVYLFLGLFLFKRIRLNKPINSQLRNLNIPKIKETLISDQVKQSPVLP
KFSKKLNDIPLQSRKRIYCLHKDDDYIDRNDSSSVSTFSNTCKNSNERPS
NVLDLDMLTEKIKQGLGHELSDTEILQLLSHGRLKTRELESVVRNPFRAV
ELRRLDLSTFLNNPHIIERIPYKDYDYRLVYGQCCEEVIGYMPIPVGKIG
PLLLDGRSHYIPLATTEGCLVASTNRGCRAIFLAGGIKSVVYRDQMTRAP
VVWFPSIIDSVKCIAWIDSEEGFQTLKSAFDKTSAHVNLLSVFACPAGRY
IHIRFAARTGDAMGMNMVSKATDSALHCLKKYFSNMQVISLSGNMCTDKK
PATINTILGRGKSVIAEAHLSADVLAQVLHTNAQRLARLTHSKNWIGSAM
AGCPGMMGCNAHAANIIAGMFAATGQDLAQVVDSSSCLTQLEVDLSDDSL
VASVTMPCLEVGTVGGGTRLSGQRACLDLLDLSVDRPTEHLSRIIAGTVL
AAELSLMAALDTDDLVKAHMHFNRAKQSTNSHSCSHSTTTDNNDNISNIY
DNHNVALSSKIPVTDNSDIRESVHSLHVKPFPVKSDLSVNPEISHYTM</Seq>
	</Sequence>
	<Topology numTM="9" reliability="64.6591">
		<Region from="1" to="7" loc="I"/>
		<Region from="8" to="29" loc="M"/>
		<Region from="30" to="49" loc="O"/>
		<Region from="50" to="71" loc="M"/>
		<Region from="72" to="91" loc="I"/>
		<Region from="92" to="112" loc="M"/>
		<Region from="113" to="118" loc="O"/>
		<Region from="119" to="140" loc="M"/>
		<Region from="141" to="170" loc="I"/>
		<Region from="171" to="186" loc="M"/>
		<Region from="187" to="206" loc="O"/>
		<Region from="207" to="228" loc="M"/>
		<Region from="229" to="286" loc="I"/>
		<Region from="287" to="302" loc="M"/>
		<Region from="303" to="340" loc="O"/>
		<Region from="341" to="362" loc="M"/>
		<Region from="363" to="745" loc="I"/>
		<Region from="746" to="761" loc="M"/>
		<Region from="762" to="948" loc="O"/>
	</Topology>
	<Predictions>
		<Prediction name="HMMTOP">
			<Region from="1" to="6" loc="I"/>
			<Region from="7" to="28" loc="M"/>
			<Region from="29" to="53" loc="O"/>
			<Region from="54" to="70" loc="M"/>
			<Region from="71" to="90" loc="I"/>
			<Region from="91" to="112" loc="M"/>
			<Region from="113" to="118" loc="O"/>
			<Region from="119" to="140" loc="M"/>
			<Region from="141" to="169" loc="I"/>
			<Region from="170" to="186" loc="M"/>
			<Region from="187" to="206" loc="O"/>
			<Region from="207" to="228" loc="M"/>
			<Region from="229" to="285" loc="I"/>
			<Region from="286" to="302" loc="M"/>
			<Region from="303" to="948" loc="O"/>
		</Prediction>
		<Prediction name="Memsat">
			<Region from="1" to="13" loc="O"/>
			<Region from="14" to="29" loc="M"/>
			<Region from="30" to="47" loc="I"/>
			<Region from="48" to="71" loc="M"/>
			<Region from="72" to="92" loc="O"/>
			<Region from="93" to="113" loc="M"/>
			<Region from="114" to="116" loc="I"/>
			<Region from="117" to="144" loc="M"/>
			<Region from="145" to="198" loc="O"/>
			<Region from="199" to="224" loc="M"/>
			<Region from="225" to="285" loc="I"/>
			<Region from="286" to="301" loc="M"/>
			<Region from="302" to="340" loc="O"/>
			<Region from="341" to="362" loc="M"/>
			<Region from="363" to="948" loc="I"/>
		</Prediction>
		<Prediction name="Octopus">
			<Region from="1" to="7" loc="I"/>
			<Region from="8" to="28" loc="M"/>
			<Region from="29" to="49" loc="O"/>
			<Region from="50" to="70" loc="M"/>
			<Region from="71" to="94" loc="I"/>
			<Region from="95" to="115" loc="M"/>
			<Region from="116" to="122" loc="O"/>
			<Region from="123" to="143" loc="M"/>
			<Region from="144" to="201" loc="I"/>
			<Region from="202" to="222" loc="M"/>
			<Region from="223" to="285" loc="O"/>
			<Region from="286" to="306" loc="M"/>
			<Region from="307" to="342" loc="I"/>
			<Region from="343" to="363" loc="M"/>
			<Region from="364" to="841" loc="O"/>
			<Region from="842" to="862" loc="M"/>
			<Region from="863" to="948" loc="I"/>
		</Prediction>
		<Prediction name="Philius">
			<Region from="1" to="7" loc="I"/>
			<Region from="8" to="29" loc="M"/>
			<Region from="30" to="48" loc="O"/>
			<Region from="49" to="71" loc="M"/>
			<Region from="72" to="90" loc="I"/>
			<Region from="91" to="112" loc="M"/>
			<Region from="113" to="118" loc="O"/>
			<Region from="119" to="140" loc="M"/>
			<Region from="141" to="163" loc="I"/>
			<Region from="164" to="184" loc="M"/>
			<Region from="185" to="206" loc="O"/>
			<Region from="207" to="226" loc="M"/>
			<Region from="227" to="283" loc="I"/>
			<Region from="284" to="303" loc="M"/>
			<Region from="304" to="339" loc="O"/>
			<Region from="340" to="363" loc="M"/>
			<Region from="364" to="744" loc="I"/>
			<Region from="745" to="764" loc="M"/>
			<Region from="765" to="948" loc="O"/>
		</Prediction>
		<Prediction name="Phobius">
			<Region from="1" to="6" loc="I"/>
			<Region from="7" to="28" loc="M"/>
			<Region from="29" to="47" loc="O"/>
			<Region from="48" to="71" loc="M"/>
			<Region from="72" to="91" loc="I"/>
			<Region from="92" to="111" loc="M"/>
			<Region from="112" to="116" loc="O"/>
			<Region from="117" to="144" loc="M"/>
			<Region from="145" to="163" loc="I"/>
			<Region from="164" to="187" loc="M"/>
			<Region from="188" to="206" loc="O"/>
			<Region from="207" to="227" loc="M"/>
			<Region from="228" to="283" loc="I"/>
			<Region from="284" to="302" loc="M"/>
			<Region from="303" to="339" loc="O"/>
			<Region from="340" to="363" loc="M"/>
			<Region from="364" to="948" loc="I"/>
		</Prediction>
		<Prediction name="Pro">
			<Region from="1" to="9" loc="I"/>
			<Region from="10" to="30" loc="M"/>
			<Region from="31" to="50" loc="O"/>
			<Region from="51" to="71" loc="M"/>
			<Region from="72" to="91" loc="I"/>
			<Region from="92" to="112" loc="M"/>
			<Region from="113" to="116" loc="O"/>
			<Region from="117" to="137" loc="M"/>
			<Region from="138" to="157" loc="I"/>
			<Region from="158" to="178" loc="M"/>
			<Region from="179" to="206" loc="O"/>
			<Region from="207" to="227" loc="M"/>
			<Region from="228" to="948" loc="I"/>
		</Prediction>
		<Prediction name="Prodiv">
			<Region from="1" to="746" loc="I"/>
			<Region from="747" to="770" loc="M"/>
			<Region from="771" to="842" loc="O"/>
			<Region from="843" to="863" loc="M"/>
			<Region from="864" to="948" loc="I"/>
		</Prediction>
		<Prediction name="Scampi">
			<Region from="1" to="10" loc="I"/>
			<Region from="11" to="31" loc="M"/>
			<Region from="32" to="48" loc="O"/>
			<Region from="49" to="69" loc="M"/>
			<Region from="70" to="91" loc="I"/>
			<Region from="92" to="112" loc="M"/>
			<Region from="113" to="124" loc="O"/>
			<Region from="125" to="145" loc="M"/>
			<Region from="146" to="202" loc="I"/>
			<Region from="203" to="223" loc="M"/>
			<Region from="224" to="281" loc="O"/>
			<Region from="282" to="302" loc="M"/>
			<Region from="303" to="347" loc="I"/>
			<Region from="348" to="368" loc="M"/>
			<Region from="369" to="840" loc="O"/>
			<Region from="841" to="861" loc="M"/>
			<Region from="862" to="948" loc="I"/>
		</Prediction>
		<Prediction name="ScampiMsa">
			<Region from="1" to="10" loc="I"/>
			<Region from="11" to="30" loc="M"/>
			<Region from="31" to="48" loc="O"/>
			<Region from="49" to="68" loc="M"/>
			<Region from="69" to="91" loc="I"/>
			<Region from="92" to="111" loc="M"/>
			<Region from="112" to="124" loc="O"/>
			<Region from="125" to="144" loc="M"/>
			<Region from="145" to="174" loc="I"/>
			<Region from="175" to="194" loc="M"/>
			<Region from="195" to="204" loc="O"/>
			<Region from="205" to="224" loc="M"/>
			<Region from="225" to="285" loc="I"/>
			<Region from="286" to="305" loc="M"/>
			<Region from="306" to="342" loc="O"/>
			<Region from="343" to="362" loc="M"/>
			<Region from="363" to="840" loc="I"/>
			<Region from="841" to="860" loc="M"/>
			<Region from="861" to="948" loc="O"/>
		</Prediction>
		<Prediction name="TMHMM">
			<Region from="1" to="6" loc="I"/>
			<Region from="7" to="29" loc="M"/>
			<Region from="30" to="48" loc="O"/>
			<Region from="49" to="71" loc="M"/>
			<Region from="72" to="91" loc="I"/>
			<Region from="92" to="114" loc="M"/>
			<Region from="115" to="117" loc="O"/>
			<Region from="118" to="140" loc="M"/>
			<Region from="141" to="206" loc="I"/>
			<Region from="207" to="226" loc="M"/>
			<Region from="227" to="286" loc="O"/>
			<Region from="287" to="304" loc="M"/>
			<Region from="305" to="339" loc="I"/>
			<Region from="340" to="362" loc="M"/>
			<Region from="363" to="948" loc="O"/>
		</Prediction>
	</Predictions>
</CCTOPItem>
