TmAlphaFold Transmembrane Protein Structure Database
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Examples: tmem slco3a1 P33527 helpy
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TmAlphaFold database currently provides validation of predicted transmembrane protein structures for the organisms listed below.

You can download various files about the prediction for an individual UniProt accession by visiting the corresponding structure page (example: https://tmalphafold.ttk.hu/entry/P33527).

For downloading all predictions for a given species, use the download links below. Note that this option is only available on the desktop version of the site. The compressed files contain four files for each entry:

.pdb.gz
Pdb file containing the rotated structure, so the protein is rotated in a way that the normal vector of membrane plane is the Z axis (the XY plane is parallel to the membrane plane).
_tmdet.xml
XML file containing the tmdet result, including the transformation matrix, together with the regions determined by the TMDET algorithm, using the following notations: “M” is for segments embedding in the membrane, “G” is for non-TM residues, “F” for residues erroneously harboring the membrane and “m” for segments erroneously placed outside the membrane bilayer.
_cctop.xml
XML file containing the topology prediction result by CCTOP.
_eval.xml
XML file containing the results of evaluation tests.

Compressed files for membrane localisations and evaluations of AlphaFold predicted transmembrane protein structures for model organism proteomes:

Species Common name Reference proteome # of proteins # of TM proteins Download
Arabidopsis thaliana Mouse-ear cress UP000006548 27435 6151 Download 400 Mb
Caenorhabditis elegans Nematode worm UP000001940 19691 6409 Download 372 Mb
Danio rerio Zebrafish UP000000437 24664 6966 Download 505 Mb
Drosophila melanogaster Fruit fly UP000000803 13459 3251 Download 243 Mb
Escherichia coli E. coli UP000000625 4363 1016 Download 50 Mb
Homo sapiens Human UP000005640 20502 5205 Download 401 Mb
Methanocaldococcus jannaschii M. jannaschii UP000000805 1773 325 Download 12 Mb
Saccharomyces cerevisiae Baker's yeast UP000002311 6041 1289 Download 98 Mb
Candida albicans Yeast UP000000559 5974 1429 Download 102 Mb
Mus musculus Mouse UP000000589 21613 6429 Download 468 Mb
Dictyostelium discoideum Slime mold UP000002195 12622 2804 Download 215 Mb
Schizosaccharomyces pombe Fission yeast UP000002485 5128 1020 Download 73 Mb
Rattus norvegicus Rat UP000002494 20659 5660 Download 408 Mb
Zea mays Maize UP000007305 39298 8802 Download 518 Mb
Glycine max Soybean UP000008827 55799 13737 Download 812 Mb
Oryza sativa subsp. japonica Rice UP000059680 43649 8313 Download 424 Mb

Compressed files for membrane localisations and evaluations of AlphaFold predicted transmembrane protein structures for global health proteomes:

Species Common name Reference proteome # of proteins # of TM proteins Download
Plasmodium falciparum P. falciparum UP000001450 5183 1849 Download 191 Mb
Helicobacter pylori H. pylori UP000000429 1538 310 Download 14 Mb
Neisseria gonorrhoeae N. gonorrhoeae UP000000535 2106 385 Download 16 Mb
Haemophilus influenzae H. influenzae UP000000579 1661 348 Download 16 Mb
Streptococcus pneumoniae S. pneumoniae UP000000586 2030 473 Download 21 Mb
Campylobacter jejuni subsp. jejuni serotype O:2 S. pneumoniae UP000000799 1620 384 Download 18 Mb
Mycobacterium leprae Mycobacterium leprae UP000000806 1602 354 Download 17 Mb
Salmonella typhimurium S. typhimurium UP000001014 4526 1042 Download 51 Mb
Mycobacterium tuberculosis M. tuberculosis UP000001584 3988 770 Download 39 Mb
Ajellomyces capsulatus Darling's disease fungus UP000001631 9199 1749 Download 116 Mb
Paracoccidioides lutzii Paracoccidioides lutzii UP000002059 8794 1610 Download 112 Mb
Trypanosoma cruzi Trypanosoma cruzi UP000002296 19036 5900 Download 343 Mb
Pseudomonas aeruginosa Pseudomonas aeruginosa UP000002438 5556 1277 Download 65 Mb
Shigella dysenteriae serotype 1 Shigella dysenteriae serotype 1 UP000002716 3893 775 Download 36 Mb
Nocardia brasiliensis ATCC 700358 Nocardia brasiliensis ATCC 700358 UP000006304 8372 1647 Download 75 Mb
Brugia malayi Filarial nematode worm UP000006672 8743 2202 Download 140 Mb
Klebsiella pneumoniae subsp. pneumoniae Klebsiella pneumoniae subsp. pneumoniae UP000007841 5727 1265 Download 58 Mb
Leishmania infantum Leishmania infantum UP000008153 7924 1680 Download 125 Mb
Trypanosoma brucei brucei Trypanosoma brucei brucei UP000008524 8491 2026 Download 117 Mb
Staphylococcus aureus Staphylococcus aureus UP000008816 2888 724 Download 30 Mb
Schistosoma mansoni Blood fluke UP000008854 13865 3272 Download 268 Mb
Sporothrix schenckii Rose-picker's disease fungus UP000018087 8652 2033 Download 151 Mb
Mycobacterium ulcerans str. Harvey Mycobacterium ulcerans str. Harvey UP000020681 9033 1317 Download 38 Mb
Onchocerca volvulus Onchocerca volvulus UP000024404 12047 3186 Download 191 Mb
Trichuris trichiura Whipworm UP000030665 9564 2143 Download 146 Mb
Strongyloides stercoralis Threadworm UP000035681 12613 3662 Download 243 Mb
Fonsecaea pedrosoi CBS 271.37 Fonsecaea pedrosoi CBS 271.37 UP000053029 12509 3028 Download 214 Mb
Madurella mycetomatis Madurella mycetomatis UP000078237 9561 2115 Download 142 Mb
Cladophialophora carrionii Cladophialophora carrionii UP000094526 11170 2560 Download 176 Mb
Wuchereria bancrofti Wuchereria bancrofti UP000270924 12721 2877 Download 141 Mb
Dracunculus medinensis Guinea worm UP000274756 10834 2839 Download 162 Mb
Enterococcus faecium Enterococcus faecium UP000325664 2823 730 Download 34 Mb

Compressed files for membrane localisations and evaluations of AlphaFold predicted transmembrane protein structures for SwissProt entries:

# of proteins # of TM proteins Download
542375 80506 Download 4630 Mb

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License
Data is available for academic and commercial use, under a CC-BY-4.0 license.
If you make use of TmAlphaFold database, please cite:
Dobson L, Szekeres LI, Gerdán C, Langó T, Zeke A and Tusnady GE (2022) TmAlphaFold database: membrane localization and evaluation of AlphaFold2 predicted alpha-helical transmembrane protein structures. Nucleic Acids Research, gkac928 [Journal][DOI].
TmAlphaFold database © Copyright (2022) Institute of Enzymology, RCNS.
Feedback
If you want to share feedback on validation of transmembrane proteins AlphaFold structure prediction please contact tmalphafold@ttk.hu. If you have feedback on the website or experience any bugs please contact tmafdbhelp@ttk.hu.
Disclaimer
The TmAlphaFold database and other information provided on this site is for theoretical modelling only, caution should be exercised in its use. It is provided 'as-is' without any warranty of any kind, whether expressed or implied. For clarity, no warranty is given that use of the information shall not infringe the rights of any third party. The information is not intended to be a substitute for professional medical advice, diagnosis, or treatment, and does not constitute medical or other professional advice.
Use of the TmAlphaFold database is subject to RCNS Terms of Use.
TmAlphaFold - Server version: v1.1.0. - Database version: v1.1.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS