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Endothelin receptor type B

Membrane embeded form and evaluation of AlphaFold structure

P24530

Gene name(s): EDNRB
Source Organism: Homo sapiens
Subcellular localisation: Cell membrane
UniProt: EDNRB_HUMAN go to UniProt
AlphaFold at EBI: go to AlphaFold DB
TMDET result: qValue: 73.97
CCTOP result: Evidence level: 3D,
Reliability: 90.34
Evaluation result: Good

Available downloads:

Transformed PDB file: Pdb file containing the rotated structure, so the protein is rotated in a way that the normal vector of membrane plane is the Z axis (the XY plane is parallel to the membrane plane).
Tmdet xml file: XML file containing the tmdet result, including the transformation matrix, together with the regions determined by the TMDET algorithm, using the following notations: “M” is for segments embedding in the membrane, “G” is for non-TM residues, “F” for residues erroneously harboring the membrane and “m” for segments erroneously placed outside the membrane bilayer.
CCTOP xml file: XML file containing the topology prediction result by CCTOP.
Results of evaluation: XML file containing the results of evaluation tests.

Sequence

Protein topography, evaluation

AF-TMDET

CCTOP

Related entries in PDBTM

6lryA

5glhA

6igkA

6iglA

5gliA

5x93A

6k1qA

5xprA

Fragments used for evaluation

Fragment_1

Fragment_2

Fragment_3

Fragment_4

Color legend: Cleavable signal region not mebrane region (i.e in or outside) transmembrane segment in TOPDB Re-entrant loop Non-transmembrane region in membrane Transmembrane region in non-membrane region

Test	Passed
Detecting membrane plane
Signal
Full structure
Short helix
Masked segment in membrane plane
Missing transmembrane part
Domain or beta structure in membrane plane
Overpredict cctop
Underpredict cctop
Membrane plane cctop