TmAlphaFold Transmembrane Protein Structure Database
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Acid-sensing ion channel 1

Membrane embeded form and evaluation of AlphaFold structure

    P78348

Gene name(s)
ASIC1
Source Organism
Homo sapiens
Subcellular localisation
Cell membrane
UniProt
ASIC1_HUMAN go to UniProt
AlphaFold at EBI
go to AlphaFold DB
TMDET result
qValue: 53.77
CCTOP result
Evidence level: 3D,
Reliability: 95.94
Evaluation result
Good
Available downloads:
Transformed PDB file
Pdb file containing the rotated structure, so the protein is rotated in a way that the normal vector of membrane plane is the Z axis (the XY plane is parallel to the membrane plane).
Tmdet xml file
XML file containing the tmdet result, including the transformation matrix, together with the regions determined by the TMDET algorithm, using the following notations: “M” is for segments embedding in the membrane, “G” is for non-TM residues, “F” for residues erroneously harboring the membrane and “m” for segments erroneously placed outside the membrane bilayer.
CCTOP xml file
XML file containing the topology prediction result by CCTOP.
Results of evaluation
XML file containing the results of evaluation tests.
Sequence
Protein topography, evaluation
AF-TMDET
CCTOP
Related entries in PDBTM
7rnnD
6aveA
6aveB
6aveC
6vtkA
6vtkC
6vtkB
6vtlA
6vtlC
6vtlB
7cfsA
7cfsB
7cfsC
7cftA
7cftB
7cftC
4nykA
3ij4A
6l6iA
6l6iB
6l6iC
6l6nA
6l6nB
6l6nC
6cmcA
4fz0A
4fz0B
4fz0C
4fz1A
4ntwA
4ntxA
4ntyA
6l6pA
6l6pB
6l6pC
3s3wA
3s3wB
3s3wC
3s3xA
3s3xB
3s3xC
5wkuA
5wkuC
5wkuB
5wkvA
5wkvC
5wkvB
5wkxA
5wkxC
5wkxB
5wkyA
5wkyC
5wkyB
2qtsA
2qtsB
2qtsC
6x9hA
6x9hB
6x9hC
Fragments used for evaluation
Fragment_1
Fragment_2
Fragment_3
Fragment_4
Color legend: Cleavable signal region not mebrane region (i.e in or outside) transmembrane segment in TOPDB Re-entrant loop Non-transmembrane region in membrane Transmembrane region in non-membrane region
Color legend: Cleavable signal region not mebrane region (i.e in or outside) transmembrane segment in TOPDB Re-entrant loop Non-transmembrane region in membrane Transmembrane region in non-membrane region
Test Passed
Detecting membrane plane
Signal
Full structure
Short helix
Masked segment in membrane plane
Missing transmembrane part
Domain or beta structure in membrane plane
Overpredict cctop
Underpredict cctop
Membrane plane cctop

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License
Data is available for academic and commercial use, under a CC-BY-4.0 license.
If you make use of TmAlphaFold database, please cite:
Dobson L, Szekeres LI, Gerdán C, Langó T, Zeke A and Tusnady GE (2022) TmAlphaFold database: membrane localization and evaluation of AlphaFold2 predicted alpha-helical transmembrane protein structures. Nucleic Acids Research, gkac928 [Journal][DOI].
TmAlphaFold database © Copyright (2022) Institute of Enzymology, RCNS.
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Disclaimer
The TmAlphaFold database and other information provided on this site is for theoretical modelling only, caution should be exercised in its use. It is provided 'as-is' without any warranty of any kind, whether expressed or implied. For clarity, no warranty is given that use of the information shall not infringe the rights of any third party. The information is not intended to be a substitute for professional medical advice, diagnosis, or treatment, and does not constitute medical or other professional advice.
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TmAlphaFold - Server version: v1.1.0. - Database version: v1.1.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS